|
KMID : 0043320140370050575
|
|
Archives of Pharmacal Research
2014 Volume.37 No. 5 p.575 ~ p.579
|
|
|
Isochaetomium A2, a new bis(naphthodihydropyran-4-one) with antimicrobial and immunological activities from fungus Chaetomium microcephalum
|
|
Xu Guo Bo
Yang Tao
Bao Jin Ku
Fang Dong Mei
Li Guo You
|
|
|
Abstract
|
|
|
|
Isochaetomium A2 (1), a new bis(naphthodihydropyran-4-one), along with chaetochromins A (2) and B (3), was isolated from the solid-state fermented rice culture of Chaetomium microcephalum. The structure of compound 1 was elucidated on the basis of 1D and 2D NMR spectral data, and the relative configuration was confirmed by CD spectrum. Compounds 1?3 possessed significant antimicrobial activity against Escherichiacoli 1.044, Staphylococcus aureus 1.252, and Bacillus subtilis 1.079. Moreover, compounds 1?3 showed obvious inhibitory effects on mouse spleen cell proliferation with successive IC50 values of 0.52, 0.19, and 0.24 μM.
|
|
|
KEYWORD
|
|
|
Chaetomium microcephalum, Isochaetomium A2, Antimicrobial, Immunological activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|